Recent advances in the identification of the host factors involved in dengue virus replication

Yi Wang; Ping Zhang

doi:10.1007/s12250-016-3902-6

Recent advances in the identification of the host factors involved in dengue virus replication

Virol Sin. 2017 Feb;32(1):23-31. doi: 10.1007/s12250-016-3902-6. Epub 2017 Jan 24.

Authors

Yi Wang^{1

2}, Ping Zhang^{3

4}

Affiliations

¹ Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.
² Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China.
³ Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China. zhangp36@mail.sysu.edu.cn.
⁴ Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China. zhangp36@mail.sysu.edu.cn.

Abstract

Dengue virus (DENV) belongs to the genus Flavivirus of the family Flaviviridae and it is primarily transmitted via Aedes aegypti and Aedes albopictus mosquitoes. The life cycle of DENV includes attachment, endocytosis, protein translation, RNA synthesis, assembly, egress, and maturation. Recent researches have indicated that a variety of host factors, including cellular proteins and microRNAs, positively or negatively regulate the DENV replication process. This review summarizes the latest findings (from 2014 to 2016) in the identification of the host factors involved in the DENV life cycle and Dengue infection.

Keywords: dengue virus (DENV); host factors; miRNAs; proteins; replication.

Publication types

Review

MeSH terms

Animals
Dengue Virus / physiology*
Host-Pathogen Interactions*
Humans
MicroRNAs / metabolism
Proteins / metabolism
Virus Replication*

Substances

MicroRNAs
Proteins