A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy

Chem Commun (Camb). 2017 Feb 7;53(12):1977-1980. doi: 10.1039/c6cc10330h.

Abstract

A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Azo Compounds / chemistry
  • Azo Compounds / pharmacology*
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Glutathione / chemistry
  • Glutathione / pharmacology*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Photochemotherapy*
  • Photons*
  • Photosensitizing Agents / chemical synthesis
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Ruthenium / chemistry
  • Ruthenium / pharmacology*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Azo Compounds
  • Photosensitizing Agents
  • Ruthenium
  • Glutathione