Abstract
A glutathione (GSH)-activatable ruthenium(ii)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.
MeSH terms
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A549 Cells
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Azo Compounds / chemistry
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Azo Compounds / pharmacology*
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Glutathione / chemistry
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Glutathione / pharmacology*
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HeLa Cells
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Humans
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Molecular Structure
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Photochemotherapy*
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Photons*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology*
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Ruthenium / chemistry
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Ruthenium / pharmacology*
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Azo Compounds
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Photosensitizing Agents
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Ruthenium
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Glutathione