Metal-organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging

Yan Zhang; Chaoqun Liu; Faming Wang; Zhen Liu; Jinsong Ren; Xiaogang Qu

doi:10.1039/c6cc09280b

Metal-organic-framework-supported immunostimulatory oligonucleotides for enhanced immune response and imaging

Chem Commun (Camb). 2017 Feb 2;53(11):1840-1843. doi: 10.1039/c6cc09280b.

Authors

Yan Zhang¹, Chaoqun Liu¹, Faming Wang¹, Zhen Liu², Jinsong Ren², Xiaogang Qu²

Affiliations

¹ Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn and University of Chinese Academy of Sciences, Beijing 100039, China.
² Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. jren@ciac.ac.cn xqu@ciac.ac.cn.

PMID: 28111662
DOI: 10.1039/c6cc09280b

Abstract

We have demonstrated the ability of iron carboxylate metal-organic frameworks to efficiently deliver unmethylated cytosine-phosphate-guanine oligonucleotides. The nanoconjugates induced a stronger immune response than did free cytosine-phosphateguanine oligonucleotides and showed T₂-magnetic resonance imaging ability both in vitro and in vivo.

MeSH terms

Adjuvants, Immunologic / chemistry*
Animals
Magnetic Resonance Imaging / methods*
Mice
Oligonucleotides / chemistry*
Oligonucleotides / immunology*
Organometallic Compounds / chemistry*
Particle Size
RAW 264.7 Cells
Surface Properties

Substances

Adjuvants, Immunologic
Oligonucleotides
Organometallic Compounds