Glycoproteins functionalized natural and synthetic polymers for prospective biomedical applications: A review

Int J Biol Macromol. 2017 May:98:748-776. doi: 10.1016/j.ijbiomac.2017.01.078. Epub 2017 Jan 19.

Abstract

Glycoproteins have multidimensional properties such as biodegradability, biocompatibility, non-toxicity, antimicrobial and adsorption properties; therefore, they have wide range of applications. They are blended with different polymers such as chitosan, carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), polycaprolactone (PCL), heparin, polystyrene fluorescent nanoparticles (PS-NPs) and carboxyl pullulan (PC) to improve their properties like thermal stability, mechanical properties, resistance to pH, chemical stability and toughness. Considering the versatile charateristics of glycoprotein based polymers, this review sheds light on synthesis and characterization of blends and composites of glycoproteins, with natural and synthetic polymers and their potential applications in biomedical field such as drug delivery system, insulin delivery, antimicrobial wound dressing uses, targeting of cancer cells, development of anticancer vaccines, development of new biopolymers, glycoproteome research, food product and detection of dengue glycoproteins. All the technical scientific issues have been addressed; highlighting the recent advancement.

Keywords: Blends and composites; Cancer treatment; Drug delivery system; Glycoproteins; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / therapeutic use
  • Biopolymers / chemistry
  • Biopolymers / therapeutic use
  • Carboxymethylcellulose Sodium / chemistry
  • Carboxymethylcellulose Sodium / therapeutic use
  • Chitosan / chemistry
  • Chitosan / therapeutic use
  • Drug Delivery Systems*
  • Glycoproteins / chemical synthesis
  • Glycoproteins / chemistry*
  • Glycoproteins / therapeutic use
  • Humans
  • Nanoparticles / chemistry
  • Nanoparticles / therapeutic use
  • Polyesters / chemistry
  • Polyesters / therapeutic use
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Polymers / therapeutic use
  • Povidone / chemistry
  • Povidone / therapeutic use

Substances

  • Biocompatible Materials
  • Biopolymers
  • Glycoproteins
  • Polyesters
  • Polymers
  • polycaprolactone
  • Chitosan
  • Povidone
  • Carboxymethylcellulose Sodium