Mechanochemically synthesized Ag-based nanohybrids with unprecedented low toxicity in biomedical applications

Environ Res. 2017 Apr:154:204-211. doi: 10.1016/j.envres.2017.01.010. Epub 2017 Jan 16.

Abstract

A simple and innovative mechanochemical approach was employed to synthesize Ag-polysaccharide nanohybrid materials that were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized Ag nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SY5Y as compared to similarly reported Ag nanomaterials due to the stability and low release of Ag+ and high biocompatibility of the nanohybrids.

Keywords: Ag nanoparticles; Biomaterials; Cytotoxicity; Mechanochemistry; Nanocomposites; Polysaccharides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • A549 Cells
  • Biomedical and Dental Materials / therapeutic use*
  • Biomedical and Dental Materials / toxicity
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • China
  • Cytotoxins / therapeutic use*
  • Cytotoxins / toxicity*
  • Humans
  • Nanostructures / therapeutic use*
  • Nanostructures / toxicity*
  • Silver / chemistry
  • Silver / therapeutic use*
  • Silver / toxicity*
  • Surface Properties
  • Toxicity Tests

Substances

  • Biomedical and Dental Materials
  • Cytotoxins
  • Silver