Osteoarthritis year in review 2016: biology

Osteoarthritis Cartilage. 2017 Feb;25(2):175-180. doi: 10.1016/j.joca.2016.09.024. Epub 2017 Jan 16.

Abstract

This review highlights a selection of literature in the area of osteoarthritis biology published between the 2015 and 2016 Osteoarthritis Research Society International (OARSI) World Congress. Highlights were selected from a pubmed search covering cartilage, bone, inflammation and pain. A personal selection was made based, amongst other things, on topics presented during the 2015 conference. This covers circadian rhythm, TGF-β signaling, autophagy, SIRT6, exercise, lubricin, TLR's, pain and NGF. Furthermore, in this review we have made an effort to connect these seemingly distant topics into one scheme of connections between them, revealing a theoretical big picture underneath.

Keywords: Cartilage; Inflammation; Osteoarthritis; Subchondral bone.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy / physiology
  • Circadian Rhythm / physiology
  • Exercise / physiology
  • Glycoproteins / physiology
  • Humans
  • Osteoarthritis / metabolism
  • Osteoarthritis / physiopathology*
  • Sirtuins / physiology
  • Transforming Growth Factor beta / physiology

Substances

  • Glycoproteins
  • Transforming Growth Factor beta
  • lubricin
  • SIRT6 protein, human
  • Sirtuins