Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin

PLoS One. 2017 Jan 17;12(1):e0169578. doi: 10.1371/journal.pone.0169578. eCollection 2017.

Abstract

The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. According to molecular modeling method, the enthalpy formation of host-guest illustrated the predominant configuration and the lowest value ΔbGo was -10.8174±1.9235 kcal/mol, suggesting the complex could reduce the energy of the system. The characterization analysis confirmed the formation of PA-CD inclusion complex, and the results indicated the advantage of the inclusion complex in stability and dissolution rates. These results identified PA-CD inclusion complex an effective way for the storage of PA, and better inclusion method still needed to be studied.

MeSH terms

  • Calorimetry, Differential Scanning
  • Inclusion Bodies / chemistry*
  • Inclusion Bodies / metabolism*
  • Models, Molecular
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / metabolism*
  • Solubility
  • Spectroscopy, Fourier Transform Infrared
  • Thermodynamics
  • X-Ray Diffraction
  • beta-Cyclodextrins / chemistry*
  • beta-Cyclodextrins / metabolism*

Substances

  • Sesquiterpenes
  • beta-Cyclodextrins
  • patchouli alcohol

Grants and funding

This work was supported by the National Natural Science Foundation of China (Nos. 81202398 and 81302868), Guangdong Provincial Science and Technology Project (Nos. 2013B010102006, 2014A020221035, and 2015A020211025), and the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine (Nos. YN2014ZHR209, YN2015MS03, YN2014ZH08, and YN2015QN03). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.