Nardonaphthalenones A and B from the roots and rhizomes of Nardostachys chinensis Batal

Bioorg Med Chem Lett. 2017 Feb 15;27(4):875-879. doi: 10.1016/j.bmcl.2017.01.008. Epub 2017 Jan 6.

Abstract

Nardonaphthalenones A and B (1-2), one new apo-α-carotenone (3) and four new monoterpenoids (4, 8-9 and 11), along with six known compounds (5-7, 10, 12-13) were isolated from the dried roots and rhizomes of Nardostachys chinensis Batal. Their structures were elucidated by analysis of the spectroscopic data including NMR, HRESIMS and circular dichroism data. Furthermore, the serotonin transporter (SERT)-regulating activities of these isolates were evaluated, among them compound 3 showed the strongest enhancement activity while compound 12 showed a moderate inhibition activity on SERT.

Keywords: Iridoid glycoside; Monoterpenoids; Nardonaphthalenone; Nardostachys chinensis Batal..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression / drug effects
  • HEK293 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology
  • Naphthalenes / chemistry*
  • Naphthalenes / isolation & purification
  • Naphthalenes / pharmacology
  • Nardostachys / chemistry*
  • Nardostachys / metabolism
  • Plant Roots / chemistry
  • Plant Roots / metabolism
  • Rhizome / chemistry
  • Rhizome / metabolism
  • Serotonin Plasma Membrane Transport Proteins / chemistry
  • Serotonin Plasma Membrane Transport Proteins / genetics
  • Serotonin Plasma Membrane Transport Proteins / metabolism

Substances

  • Monoterpenes
  • Naphthalenes
  • Serotonin Plasma Membrane Transport Proteins