Inhibition of collagen production by ICG-001, a small molecule inhibitor for Wnt/β-catenin signaling, in skin fibroblasts

J Dermatol Sci. 2017 Apr;86(1):76-78. doi: 10.1016/j.jdermsci.2017.01.005. Epub 2017 Jan 6.
No abstract available

Publication types

  • Letter

MeSH terms

  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Bridged Bicyclo Compounds, Heterocyclic / therapeutic use
  • Cicatrix, Hypertrophic / drug therapy
  • Cicatrix, Hypertrophic / pathology
  • Collagen / metabolism*
  • Drug Evaluation, Preclinical
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism
  • Humans
  • Keloid / drug therapy
  • Keloid / pathology
  • Keloid / surgery
  • Primary Cell Culture
  • Pyrimidinones / pharmacology*
  • Pyrimidinones / therapeutic use
  • Skin / cytology
  • Skin / drug effects*
  • Skin / metabolism
  • Wnt Signaling Pathway / drug effects*

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • ICG 001
  • Pyrimidinones
  • Collagen