Suv39h1 links the SUMO pathway to constitutive heterochromatin

Christèle Maison; Jean-Pierre Quivy; Geneviève Almouzni

doi:10.1080/23723556.2016.1225546

Suv39h1 links the SUMO pathway to constitutive heterochromatin

Mol Cell Oncol. 2016 Aug 26;3(6):e1225546. doi: 10.1080/23723556.2016.1225546. eCollection 2016.

Authors

Christèle Maison¹, Jean-Pierre Quivy¹, Geneviève Almouzni¹

Affiliation

¹ Institut Curie, PSL Research University, CNRS, UMR3664, Equipe Labellisée Ligue contre le Cancer, Paris, France; Sorbonne Universités, UPMC Université Paris 06, CNRS, UMR3664, Paris, France.

Abstract

The Suv39h lysine methyltransferases, known as key enzymes responsible for histone H3 lysine 9 methylation, are critical for heterochromatin protein 1 enrichment at constitutive heterochromatin. Our recent findings reveal a new role for the Suv39h1 paralog that links it to SUMO pathway function at constitutive heterochromatin.

Keywords: HP1; Heterochromatin; SUMO pathway; nuclear organization; suv39h1.