Does MHC Class I Chain-Related Gene A Matter?

Aleksander Chojecki

doi:10.1016/j.bbmt.2017.01.066

Does MHC Class I Chain-Related Gene A Matter?

Biol Blood Marrow Transplant. 2017 Mar;23(3):365-366. doi: 10.1016/j.bbmt.2017.01.066. Epub 2017 Jan 11.

Author

Aleksander Chojecki¹

Affiliation

¹ Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, North Carolina. Electronic address: Aleksander.chojecki@carolinashealthcare.org.

PMID: 28088489
DOI: 10.1016/j.bbmt.2017.01.066

Abstract

In this issue of Biology of Blood and Marrow Transplantation, Askar et al. evaluate the association of MHC class I chain-related gene A (MICA) polymorphisms with the development of graft-versus host-disease (GVHD) after unrelated donor hematopoietic stem cell transplantation (HCT) [1]. Prior reports have provided conflicting results, leaving the effect of MICA donor-recipient mismatch in HCT unanswered.

Keywords: Graft-versus-host disease; MHC class I chain-related gene A polymorphisms; MICA.

MeSH terms

Graft vs Host Disease / genetics*
Hematopoietic Stem Cell Transplantation / adverse effects*
Hematopoietic Stem Cell Transplantation / methods
Histocompatibility
Histocompatibility Antigens Class I / physiology*
Humans
Polymorphism, Genetic
Transplantation, Homologous

Substances

Histocompatibility Antigens Class I
MHC class I-related chain A