The innate immune response against viral infection is mainly relies on type I interferon, the production of which is mediated by TANK-binding kinase 1 (TBK1). It is revealed that the downstream TBK1 is activated by viral nucleic acid sensors RIG-I, cGAS and TLR3. The activity of TBK1 is complexly and precisely regulated by different type of protein modifications, including phosphorylation, ubiquitination and Sumolylation. This article focuses on the role of TBK1 in anti-viral innate immunity and the regulatory mechanism for the TBK1 activation.
TANK结合激酶1（TBK1）是Ⅰ型干扰素合成过程中最为关键的蛋白激酶，在抗病毒固有免疫应答中发挥重要的作用。TBK1可以被RIG-I-MAVS、cGAS-STING和TLR3/4-TRIF抗病毒信号通路所活化，作为重要的节点蛋白，其活化受到磷酸化、泛素化、SUMO化等一系列机制复杂而精密的调控。本文对TBK1在抗病毒免疫应答中的作用及其调控机制的研究进展进行综述。