And the fat lady sings about phosphate and calcium

Carsten A Wagner; Pedro H Imenez Silva; Isabel Rubio-Aliaga

doi:10.1016/j.kint.2016.11.009

And the fat lady sings about phosphate and calcium

Kidney Int. 2017 Feb;91(2):270-272. doi: 10.1016/j.kint.2016.11.009.

Authors

Carsten A Wagner¹, Pedro H Imenez Silva², Isabel Rubio-Aliaga²

Affiliations

¹ Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland. Electronic address: Wagnerca@access.uzh.ch.
² Institute of Physiology, University of Zurich, Switzerland, and NCCR Kidney.CH, Switzerland.

PMID: 28087005
DOI: 10.1016/j.kint.2016.11.009

Abstract

Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity.

Publication types

Comment

MeSH terms

Adipose Tissue
Calcium*
Calcium, Dietary*
Homeostasis
Phosphates

Substances

Calcium, Dietary
Phosphates
Calcium