BCR-ABL translocation as a favorable prognostic factor in elderly patients with acute lymphoblastic leukemia in the era of potent tyrosine kinase inhibitors

Ja Min Byun; Youngil Koh; Dong-Yeop Shin; Inho Kim; Sung-Soo Yoon; Jeong-Ok Lee; Soo-Mee Bang; Ki Hwan Kim; Sung-Hoon Jung; Won Sik Lee; Yong Park; Jun Ho Jang; Jae Joon Han; Ho-Young Yhim; Dae Sik Kim; Yoo Jin Lee; Hyewon Lee; Yun-Suk Choi; Seok Lee; Korean Adult ALL Working Party, Korean Society of Hematology

doi:10.3324/haematol.2016.159988

BCR-ABL translocation as a favorable prognostic factor in elderly patients with acute lymphoblastic leukemia in the era of potent tyrosine kinase inhibitors

Haematologica. 2017 May;102(5):e187-e190. doi: 10.3324/haematol.2016.159988. Epub 2017 Jan 12.

Authors

Ja Min Byun^{1

2

3}, Youngil Koh⁴, Dong-Yeop Shin¹, Inho Kim¹, Sung-Soo Yoon¹, Jeong-Ok Lee², Soo-Mee Bang², Ki Hwan Kim³, Sung-Hoon Jung⁵, Won Sik Lee⁶, Yong Park⁷, Jun Ho Jang⁸, Jae Joon Han⁹, Ho-Young Yhim¹⁰, Dae Sik Kim¹¹, Yoo Jin Lee¹², Hyewon Lee¹³, Yun-Suk Choi¹⁴, Seok Lee¹⁵; Korean Adult ALL Working Party, Korean Society of Hematology

Affiliations

¹ Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
² Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul, Korea.
³ Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
⁴ Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea go01@snu.ac.kr.
⁵ Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Seoul, Korea.
⁶ Department of Internal Medicine, Inje University Busan Paik Hospital, Seoul, Korea.
⁷ Department of Internal Medicine, Korea University School of Medicine Anam Hospital, Seoul, Korea.
⁸ Divison of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
⁹ Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
¹⁰ Division of Hematology-Oncology, Department of Internal Medicine, Chonbuk National University Hospital, Seoul, Korea.
¹¹ Department of Internal Medicine, Korea University School of Medicine, Seoul, Korea.
¹² Department of Hematology-Oncology, Kyungpook National University Hospital, Goyang, Korea.
¹³ Hematologic-Oncology Clinic, Center for Specific Organs Cancer, National Cancer Center, Goyang, Korea.
¹⁴ Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine, Korea.
¹⁵ Department of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Korea.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Aged
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Biomarkers, Tumor
Fusion Proteins, bcr-abl / antagonists & inhibitors
Fusion Proteins, bcr-abl / genetics*
Humans
Kaplan-Meier Estimate
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
Prognosis
Protein Kinase Inhibitors / therapeutic use
Treatment Outcome

Substances

Antineoplastic Agents
Biomarkers, Tumor
Protein Kinase Inhibitors
Fusion Proteins, bcr-abl