Application of Organic Monolithic Materials to Enantioseparation in Capillary Separation Techniques

Abstract

This review article is primarily focused on the state-of-the-art of enantioseparations on organic monolithic materials. The article gives an overview of the chiral stationary phases and its application in capillary electrochromatography (CEC), and capillary- and nano-liquid chromatography (cLC and nLC). Since thousands of publications have been emerged from 2000's and citing all these papers would extend the scope of this review; then, recent developments from last 10 years (2006 to 2016) will be mentioned. Mostly, stationary phases based on copolymers obtained from chiral functional monomers and surface modifications of organic monoliths with chiral ligands will be discussed. The effective application of these chiral separation methodologies in several analysis areas will be also included.

Keywords: Organic monolithic materials; capillary electrochromatography; capillary separation techniques; chiral selectors; chiral stationary phases; cyclodextrins; enantioseparation; molecularly imprinted polymers.