Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

Guohai Chen; Radouil Tzekov; Wensheng Li; Fangzheng Jiang; Sihong Mao; Yuhua Tong

doi:10.1371/journal.pone.0169152

Subfoveal Choroidal Thickness in Central Serous Chorioretinopathy: A Meta-Analysis

PLoS One. 2017 Jan 11;12(1):e0169152. doi: 10.1371/journal.pone.0169152. eCollection 2017.

Authors

Guohai Chen¹, Radouil Tzekov^{2

3}, Wensheng Li⁴, Fangzheng Jiang¹, Sihong Mao¹, Yuhua Tong¹

Affiliations

¹ Department of Ophthalmology, Quzhou People's Hospital, Quzhou, Zhejiang, PR China.
² Department of Ophthalmology, University of South Florida, Tampa, Florida, United States of America.
³ The Roskamp Institute, Sarasota, Florida, United States of America.
⁴ Xiamen Eye Center of Xiamen University, Xiamen, Fujian, PR China.

Abstract

Purpose: To evaluate the relationship between subfoveal choroidal thickness (SFCT) and eyes with central serous chorioretinopathy (CSC) versus fellow or control eyes.

Methods: We performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference (WMD) was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls.

Results: Twelve studies were selected for this meta-analysis, including 1108 eyes (397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls). The meta-analysis clearly demonstrated that the subfoveal choiroid of eyes with a clinical presentation of CSC was thickened compared to unaffected fellow eyes (WMD = 52.81, 95% confidence interval (CI), 39.13-66.49, P<0.00001) and was thickened compared to control eyes (WMD = 145.03, 95%CI, 121.33-168.73, P<0.00001). The mean SFCT measurement of the unaffected fellow eyes showed also significantly increased choroidal thickness compared to that of normal control eyes (WMD = 77.20, 95% CI, 44.98-109.42, P<0.00001). Similar results were obtained in a sub-analysis based on the same instrument.

Conclusion: It is demonstrated that SFCT is significantly increased in eyes with clinical manifestation of CSC, and in the clinically non-manifested fellow eyes. These results support the hypothesis that CSC is a bilateral disorder with an initial unilateral clinical presentation.

Publication types

Meta-Analysis

MeSH terms

Adult
Case-Control Studies
Central Serous Chorioretinopathy / diagnosis
Central Serous Chorioretinopathy / pathology*
Choroid / diagnostic imaging
Choroid / pathology*
Female
Fluorescein Angiography
Humans
Male
Middle Aged
Organ Size
Tomography, Optical Coherence
Visual Acuity

Grants and funding

The study design, data collection and analysis, decision to publish, and preparation of the manuscript were supported by grants from the National Natural Science Foundation of China (No. 81570875 to WL [http://www.nsfc.gov.cn]); the Health Systems Young Personnel Training Projects Foundation in Fujian Province of China (No. 2013-ZQN-JC-37 to WL [http://www.fjhfpc.gov.cn]) and Science and Technology Program Foundation of Xiamen City in China (No. 3502720144044 to WL [http://www.xminfo.net.cn]).