Non-Coding RNAs: The New Insight on Hypertrophic Scar

J Cell Biochem. 2017 Aug;118(8):1965-1968. doi: 10.1002/jcb.25873. Epub 2017 Apr 18.

Abstract

Hypertrophic scarring (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Numerous studies have reported that non-coding RNAs (ncRNAs) including microRNAs (miRNAs, miRs) and long non-coding RNAs (lncRNAs) play important roles in HS formation. Exploring non-coding RNA-based methods to treat scar would be instrumental for devising new effective therapies against scar. J. Cell. Biochem. 118: 1965-1968, 2017. © 2017 Wiley Periodicals, Inc.

Keywords: HYPERTROPHIC SCAR; NON-CODING RNAs; lncRNAs; miRNAs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Actins / metabolism
  • Cell Proliferation
  • Cicatrix, Hypertrophic / genetics
  • Cicatrix, Hypertrophic / metabolism
  • Cicatrix, Hypertrophic / pathology
  • Cicatrix, Hypertrophic / therapy*
  • Collagen / genetics
  • Collagen / metabolism
  • Extracellular Matrix / genetics
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix / pathology
  • Fibroblasts / metabolism*
  • Fibroblasts / pathology
  • Gene Expression Regulation
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism
  • RNA, Long Noncoding / therapeutic use*
  • Signal Transduction
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / metabolism

Substances

  • ACTA2 protein, human
  • Actins
  • MicroRNAs
  • RNA, Long Noncoding
  • Transforming Growth Factor beta
  • Collagen