Convenient access to 5-arylisoindolo[2,1- α]quinolin-11(6a H)-ones

Melissa O'Brien; Rachael Weagle; Donald Corkum; Minati Kuanar; Prabhu P Mohapatra; Amitabh Jha

doi:10.1007/s11030-016-9718-3

Convenient access to 5-arylisoindolo[2,1- α]quinolin-11(6a H)-ones

Mol Divers. 2017 May;21(2):455-462. doi: 10.1007/s11030-016-9718-3. Epub 2017 Jan 5.

Authors

Melissa O'Brien¹, Rachael Weagle¹, Donald Corkum¹, Minati Kuanar¹, Prabhu P Mohapatra¹, Amitabh Jha²

Affiliations

¹ Department of Chemistry, Acadia University, Wolfville, NS, Canada.
² Department of Chemistry, Acadia University, Wolfville, NS, Canada. amitabh.jha@acadiau.ca.

PMID: 28058523
DOI: 10.1007/s11030-016-9718-3

Abstract

Substituted isoindoloquinolinones were obtained from N-aryl-3-hydroxyisoindolinones and aryl alkynes under Lewis acid-catalyzed conditions in 30-99% yields.

Keywords: Aryl alkynes; Inverse electron demand cycloaddition; Lewis acid; N-Acyliminium ion; N-Aryl-3-hydroxyisoindolinones.

MeSH terms

Drug Design*
Isoindoles / chemistry*
Quinolones / chemical synthesis
Quinolones / chemistry*

Substances

Isoindoles
Quinolones