A new pyridine alkaloid from Zingiberis rhizoma

Nat Prod Res. 2017 Jul;31(13):1486-1489. doi: 10.1080/14786419.2016.1277347. Epub 2017 Jan 6.

Abstract

A new alkaloid, named 2-methoxy-4-(2-(2-pyridine)-ethyl) phenol (1), together with two known compounds, was isolated from Zingiberis rhizoma. Their structures were elucidated on the basis of 1D and 2D NMR spectra and MS spectra. Compound 1 exhibited substantial bioactivity against Canidia albicans ATCC 10231 with a minimum inhibitory concentration of 1.0 mg/mL.

Keywords: 2-Methoxy-4-(2-(2-pyridine)-ethyl) phenol; Cyclo-(4-methyl-R-Pro-S-Nva); Zingiberis rhizoma; antibacterial activity; antifungal activity; zingerone.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification
  • Antifungal Agents / pharmacology
  • Candida albicans / drug effects
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phenols / analysis
  • Plant Extracts / chemistry
  • Pyridines
  • Rhizome / chemistry*

Substances

  • Alkaloids
  • Antifungal Agents
  • Phenols
  • Plant Extracts
  • Pyridines
  • pyridine