Extracellular Remodeling by Lysosomes: An Inside-Out Mechanism of Spine Plasticity

Paul R Evans; Ryohei Yasuda

doi:10.1016/j.neuron.2016.12.025

Extracellular Remodeling by Lysosomes: An Inside-Out Mechanism of Spine Plasticity

Neuron. 2017 Jan 4;93(1):6-8. doi: 10.1016/j.neuron.2016.12.025.

Authors

Paul R Evans¹, Ryohei Yasuda²

Affiliations

¹ Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
² Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA. Electronic address: ryohei.yasuda@mpfi.org.

PMID: 28056345
DOI: 10.1016/j.neuron.2016.12.025

Abstract

In this issue of Neuron, Padamsey et al. (2017) demonstrate that neuronal activity triggers lysosomal fusion with the plasma membrane in dendrites. Quite unexpectedly, the lysosomes release signaling molecules that induce extracellular matrix remodeling to support long-lasting dendritic spine plasticity.

MeSH terms

Dendrites*
Dendritic Spines
Lysosomes
Neuronal Plasticity*
Neurons