Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease.
Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress - and CML.
Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied.
Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03-2.58, p = 0.04). The association was not significant among men.
Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study.
Conclusion: Accumulation of CML may be an adverse health consequence of SDB.
Keywords: Apnea–Hypopnea Index; Carboxymethyl-lysine; advanced glycation end-product; oxidative stress; sleep-disordered breathing.