Aim of study: The aim of the study is to show the possible differences on the same temperature and treatment time as control parameter of the variety of local hyperthermia techniques, pointing the possible differences in the local and systemic actions.
Materials and methods: Debate about the apparent locality of malignancy and the problems of the local treatment.
Results: Consider the physiological feedback mechanisms, the spread of temperature, and the time which has active role in the spreading.
Conclusion: Points that the clinical results depend not only on the temperature but also on the technical solution of the heat delivery.