PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

Jerzy Kotlinowski; Alicja Jozkowicz

doi:10.1155/2016/8492353

PPAR Gamma and Angiogenesis: Endothelial Cells Perspective

J Diabetes Res. 2016:2016:8492353. doi: 10.1155/2016/8492353. Epub 2016 Dec 7.

Authors

Jerzy Kotlinowski¹, Alicja Jozkowicz²

Affiliations

¹ Department of General Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
² Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Abstract

We summarize the current knowledge concerning PPARγ function in angiogenesis. We discuss the mechanisms of action for PPARγ and its role in vasculature development and homeostasis, focusing on endothelial cells, endothelial progenitor cells, and bone marrow-derived proangiogenic cells.

Publication types

Review

MeSH terms

Animals
Bone Marrow Cells / cytology
Cell Movement
Endothelial Cells / cytology
Homeostasis
Humans
Ligands
Mice
Mice, Knockout
Neovascularization, Pathologic*
PPAR gamma / metabolism
PPAR gamma / physiology*
Stem Cells / cytology
Transcription Factors / metabolism
Vascular Endothelial Growth Factor A / metabolism

Substances

Ligands
PPAR gamma
Transcription Factors
Vascular Endothelial Growth Factor A