Plasmids of Distinct IncK Lineages Show Compatible Phenotypes

Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01954-16. doi: 10.1128/AAC.01954-16. Print 2017 Mar.

Abstract

IncK plasmids are some of the main carriers of blaCTX-M-14 and blaCMY-2 genes and show high similarity to other plasmids belonging to the I complex, including IncB/O plasmids. Here, we studied the phylogenetic relationship of 37 newly sequenced IncK and IncB/O plasmids. We show that IncK plasmids can be divided into two compatible lineages named IncK1 and IncK2.

Keywords: IncK; incompatibility; plasmid.

MeSH terms

  • Conjugation, Genetic
  • Escherichia coli / classification
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics*
  • Escherichia coli Proteins / metabolism
  • Gene Expression
  • Humans
  • Phenotype*
  • Phylogeny*
  • Plasmids / chemistry
  • Plasmids / classification*
  • Plasmids / metabolism
  • Sequence Analysis, DNA
  • Transformation, Bacterial
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • Escherichia coli Proteins
  • beta-lactamase CTX-M-14, E coli
  • beta-Lactamases
  • beta-lactamase CMY-2, E coli