Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships

Shaodan Chen; Xiangmin Li; Tianqiao Yong; Zhanggen Wang; Jiyan Su; Chunwei Jiao; Yizhen Xie; Burton B Yang

doi:10.18632/oncotarget.14336

Cytotoxic lanostane-type triterpenoids from the fruiting bodies of Ganoderma lucidum and their structure-activity relationships

Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.

Authors

Shaodan Chen^{1

2}, Xiangmin Li^{1

2}, Tianqiao Yong^{1

2}, Zhanggen Wang³, Jiyan Su^{1

2}, Chunwei Jiao², Yizhen Xie^{1

2}, Burton B Yang^{4

5}

Affiliations

¹ State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.
² Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
³ College of Chinese Materia Medica, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.
⁴ Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada.
⁵ Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

Abstract

We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds.

Keywords: 3D-QSAR; Ganoderma lucidum; cytotoxicity; lanostane-type triterpenoids.

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Breast Neoplasms / drug therapy*
Breast Neoplasms / pathology
Carcinoma, Hepatocellular / drug therapy*
Carcinoma, Hepatocellular / pathology
Cell Survival / drug effects
Dose-Response Relationship, Drug
Female
Fruiting Bodies, Fungal / chemistry*
Hep G2 Cells
Humans
Inhibitory Concentration 50
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Molecular Conformation
Molecular Docking Simulation
Quantitative Structure-Activity Relationship
Reishi / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Antineoplastic Agents
Triterpenes