Tuning the Molar Composition of "Charge-Shifting" Cationic Copolymers Based on 2-(N,N-Dimethylamino)Ethyl Acrylate and 2-(tert-Boc-Amino)Ethyl Acrylate

Macromol Rapid Commun. 2017 Mar;38(5). doi: 10.1002/marc.201600641. Epub 2017 Jan 3.

Abstract

Copolymers of 2-(N,N-dimethylamino)ethyl acrylate (DMAEA) and 2-(tert-Boc-amino)ethyl acrylate (tBocAEA) are synthesized by reversible addition-fragmentation chain transfer polymerization in a controlled manner with defined molar masses and narrow molar masses distributions (Ð ≤ 1.17). Molar compositions of the P(DMAEA-co-tBocAEA) copolymers are assessed by means of 1 H NMR. A complete screening in molar composition is studied from 0% of DMAEA to 100% of DMAEA. Reactivity ratios of both comonomers are determined by the extended Kelen-Tüdos method (r DMAEA = 0.81 and rtBocAEA = 0.99).

Keywords: 2-(N,N-dimethylamino)ethyl acrylate; 2-(tert-Boc-amino)ethyl acrylate; RAFT polymerization; extended Kelen-Tüdos method; reactivity ratios.

MeSH terms

  • Acrylic Resins / chemistry*
  • Cations / chemical synthesis
  • Cations / chemistry
  • DNA / chemistry
  • Molecular Structure
  • Plasmids / chemistry
  • Polymerization
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Static Electricity

Substances

  • Acrylic Resins
  • Cations
  • Polymers
  • poly(2-(N,N-dimethylamino)ethyl acrylate-co-2-(tert-Boc-amino)ethyl acrylate)
  • DNA