Right ventricular reverse remodelling in Idiopathic Pulmonary Arterial Hypertension diagnosed during pregnancy: Is it possible?

Giuseppe Paciocco; Andrea Lombi; Antonella Vincenzi; Alberto Pesci; Felice Achilli

doi:10.1016/j.rmcr.2016.11.011

Right ventricular reverse remodelling in Idiopathic Pulmonary Arterial Hypertension diagnosed during pregnancy: Is it possible?

Respir Med Case Rep. 2016 Nov 24:20:59-60. doi: 10.1016/j.rmcr.2016.11.011. eCollection 2017.

Authors

Giuseppe Paciocco¹, Andrea Lombi¹, Antonella Vincenzi², Alberto Pesci¹, Felice Achilli²

Affiliations

¹ Department of Health Science, Pulmonology Unit, University of Milan Bicocca, San Gerardo Hospital, Monza, Italy.
² Department of Health Science, Cardiology Unit, San Gerardo Hospital, Monza, Italy.

Abstract

We present a case of a 36-year-old woman who developed a severe form of Idiopathic Pulmonary Arterial Hypertension (IPAH) during pregnancy and after emergency delivery. The management of IPAH during or after pregnancy is complex. Due to the severity of her IPAH, an upfront triple combination therapy, including i.v. epoprostenol, was started. The rapid institution of this treatment regimen allowed a complete right ventricular reverse remodelling after 1 year of therapy, leading to a down-titration until complete suspension of epoprostenol from the treatment regimen.

Keywords: Idiopathic pulmonary arterial hypertension; Pregnancy; Right ventricular failure; Right ventricular remodelling; Triple combination therapy.

Publication types

Case Reports