New phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti-inflammatory activity

Fitoterapia. 2017 Mar:117:11-15. doi: 10.1016/j.fitote.2016.12.007. Epub 2016 Dec 23.

Abstract

The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as xanthiumnolics A-E (1-5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC50 value of 8.73μM.

Keywords: Anti-inflammatory activities; Phenylpropanoids; RAW 264.7; X. sibiricum.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Fruit / chemistry*
  • Lipopolysaccharides
  • Macrophages / drug effects*
  • Mice
  • Molecular Structure
  • Nitric Oxide / chemistry
  • Phytochemicals / chemistry*
  • Phytochemicals / isolation & purification
  • Plant Extracts / chemistry
  • RAW 264.7 Cells
  • Xanthium / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Lipopolysaccharides
  • Phytochemicals
  • Plant Extracts
  • Nitric Oxide