Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

Bo Peng; Chunrong Liu; Zhen Li; Jacob J Day; Yun Lu; David J Lefer; Ming Xian

doi:10.1016/j.bmcl.2016.12.023

Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models

Bioorg Med Chem Lett. 2017 Feb 1;27(3):542-545. doi: 10.1016/j.bmcl.2016.12.023. Epub 2016 Dec 9.

Authors

Bo Peng¹, Chunrong Liu¹, Zhen Li², Jacob J Day¹, Yun Lu³, David J Lefer², Ming Xian⁴

Affiliations

¹ Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
² Cardiovascular Center of Excellence, Louisiana State University Health Science Center, New Orleans, LA 70112, USA.
³ Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 62026, USA.
⁴ Department of Chemistry, Washington State University, Pullman, WA 99164, USA. Electronic address: mxian@wsu.edu.

Abstract

Here we report the model studies of the reactions between NADH models (using HEH and BNAH) and sulfane sulfurs (using polysulfides). Such reactions could lead to the oxidation of NADH models and the production of hydrogen sulfide (H₂S). Kinetics of the reaction between BNAH and elemental sulfur S₈ were determined in ethanol and the second-order rate constant was found to be 0.074M^-1min^-1 (at 37°C) suggesting this is a slow process.

Keywords: Ammonium tetrathiomolybdate; Donor; Hydrogen sulfide; Oxidative damage.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Hydrogen Sulfide / chemical synthesis*
Hydrogen Sulfide / chemistry
Molecular Structure
NAD / chemistry*
Oxidation-Reduction
Sulfur Compounds / chemistry*

Substances

Sulfur Compounds
NAD
Hydrogen Sulfide

Abstract

Publication types

MeSH terms

Substances

Grants and funding