Hemocompatibility of Superhemophobic Titania Surfaces

Sanli Movafaghi; Victoria Leszczak; Wei Wang; Jonathan A Sorkin; Lakshmi P Dasi; Ketul C Popat; Arun K Kota

doi:10.1002/adhm.201600717

Hemocompatibility of Superhemophobic Titania Surfaces

Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201600717. Epub 2016 Dec 21.

Authors

Sanli Movafaghi¹, Victoria Leszczak¹, Wei Wang¹, Jonathan A Sorkin¹, Lakshmi P Dasi^{1

2

3}, Ketul C Popat^{1

2}, Arun K Kota^{1

2}

Affiliations

¹ Department of Mechanical Engineering, Colorado State University, Fort Collins, CO, 80523, USA.
² School of Biomedical Engineering, Colorado State University, Fort Collins, CO, 80523, USA.
³ Department of Biomedical Engineering, Dorothy Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.

PMID: 28000420
DOI: 10.1002/adhm.201600717

Abstract

The hemocompatibility of superhemophobic surfaces is investigated and compared with that of hemophobic surfaces and hemophilic surfaces. This analysis indicates that only those superhemophobic surfaces with a robust Cassie-Baxter state display significantly lower platelet adhesion and activation. It is envisioned that the understanding gained through this work will lead to the fabrication of improved hemocompatible, superhemophobic medical implants.

Keywords: biomaterial; hemocompatible; platelet adhesion and activation; superhemophobic; superhydrophobic; titanium-based implants.

MeSH terms

Blood Platelets / cytology
Blood Platelets / metabolism*
Humans
Materials Testing*
Platelet Adhesiveness / drug effects*
Surface Properties
Titanium / chemistry*
Titanium / pharmacology*

Substances

titanium dioxide
Titanium