Objective: To explore the effect of low-dose ionizing radiation on the platelets and leukocytes of the radiation workers. Methods: We collected data from a total number of 2 055 radiation related workers and with their cumulative doses. Data on platelets and leukocytes was gathered from physical examination of the staff members, from 2013 to 2015 in Chengdu. T test, variance analysis, χ2 test, linear correlation, covariance analysis and multivariate logistic regression analysis were used to analyze the data. Results: Results from the covariance analysis showed that with the increase of cumulative doses, the quantity of platelet and leukocyte appeared a decreasing trend. Multivariate logistic regression analysis showed that, with the increase of BMI levels and the medium cumulative dose and above (>4.333 mSv), the risk of thrombocytopenia became more obvious (trend test as P<0.05). In the group with high-dose exposure radiation (>15.639 mSv) and combined factor as smoking, the risk of developing thrombocytopenia would increase (OR=2.33, 95% CI: 1.23-4.44). Staff with cumulative dose of less than 4.332 mSv and exercised more than 1 time per week, the risk of developing low leukocyte would decrease (OR=0.26, 95% CI: 0.09-0.70). Conclusions: Along with the increase of cumulative doses on exposure to radiation related workers. The quantity of platelet and leukocyte showed a decreasing trend among them. When this high-dose exposure radiation combined with overweight/obesity or cigarette smoking, the risk of developing thrombocytopenia was high. However, physical exercise might have served as protective factor on leukopenia.