Abstract
Combination vaccines reduce the 'shot burden' and simplify the childhood immunization schedule. Only 5-valent DTaP-based vaccines are licensed in the U.S. Areas covered: A new combination vaccine - DTaP5-IPV-Hib-HepB - is described, which induces antibody responses in infants (given in different schedules, including a 2, 4, and 6-month schedule) that are similar to the respective component vaccines. The vaccine appears to be safe and would be expected to protect against six diseases: diphtheria, tetanus, pertussis, hepatitis B, H influenzae type b, and polio. Administration is associated with higher rates of mild fever, but without significant safety signals. Expert commentary: Incorporation of this hexavalent vaccine into the U.S. schedule could improve coverage rates and timeliness, and addition to the E.U. market would add depth to the available repertoire of combination vaccines.
Keywords:
Diphtheria; Hepatitis B; Hib; Polio; combination vaccine; hexavalent; immunogenicity; pertussis; safety; tetanus; vaccine.
Publication types
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Review
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / blood
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Antibodies, Viral / blood
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Child, Preschool
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Diphtheria / prevention & control
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage*
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Drug-Related Side Effects and Adverse Reactions / epidemiology
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Drug-Related Side Effects and Adverse Reactions / pathology
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Haemophilus Infections / prevention & control
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Haemophilus Vaccines / administration & dosage*
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Haemophilus Vaccines / adverse effects
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Haemophilus Vaccines / immunology*
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Hepatitis B / prevention & control
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Hepatitis B Vaccines / administration & dosage*
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Hepatitis B Vaccines / adverse effects
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Hepatitis B Vaccines / immunology*
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Humans
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Immunization Schedule
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Infant
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Poliomyelitis / prevention & control
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Poliovirus Vaccine, Inactivated / administration & dosage*
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Poliovirus Vaccine, Inactivated / adverse effects
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Poliovirus Vaccine, Inactivated / immunology*
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Tetanus / prevention & control
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United States
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Whooping Cough / prevention & control
Substances
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Antibodies, Bacterial
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Antibodies, Viral
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Hepatitis B Vaccines
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Poliovirus Vaccine, Inactivated
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Vaccines, Combined
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diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine