Complementary pharmacological and toxicological characterization data on the pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl) acetamide

Myrna Déciga-Campos; Gabriel Navarrete-Vázquez; Francisco Javier López-Muñoz; Tadeusz Librowski; Amanda Sánchez-Recillas; Victor Yañez-Pérez; Rolffy Ortiz-Andrade

doi:10.1016/j.dib.2016.07.019

Complementary pharmacological and toxicological characterization data on the pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl) acetamide

Data Brief. 2016 Jul 16:8:1007-1012. doi: 10.1016/j.dib.2016.07.019. eCollection 2016 Sep.

Authors

Myrna Déciga-Campos¹, Gabriel Navarrete-Vázquez², Francisco Javier López-Muñoz³, Tadeusz Librowski⁴, Amanda Sánchez-Recillas⁵, Victor Yañez-Pérez⁵, Rolffy Ortiz-Andrade⁵

Affiliations

¹ Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México, México.
² Facultad de Farmacia de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México.
³ Departamento de Farmacobiología, Cinvestav, Sede Sur, Ciudad de México, México.
⁴ Departament of Pharmacodynamics, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland.
⁵ Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Mérida, Yucatán, México.

Abstract

This text presents complementary data corresponding to pharmacological and toxicological characterization of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide (LIA) compound. These data support our research article entitled "Pharmacological profile of N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide, a novel analog of lidocaine" Déciga-Campos M., Navarrete-Vázquez G., López-Muñoz F.J., Librowski T., Sánchez-Recillas A., Yañez-Pérez V., Ortiz-Andrade R. (2016) [1]. Toxicity was predicted through the ACD/ToxSuite software and evaluated in vivo using brine shrimp larvae (Artemia salina L.) and mice. Also, we used the micronucleus assay to determine genotoxicity. We used the platform admetSAR to predict absorption properties of LIA and lidocaine.

Keywords: CYP-P450, cytochrome P-450; DBP, diastolic blood pressure; HR, heart rate; IC50, half maximal inhibitory concentration; LC50, half lethal concentration; LD50, half lethal dose; LIA, N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide; Lidocaine; MNPCE, micronucleated polychromatic erythrocytes; N-(2,6-dichlorophenyl)-2-(4-methyl-1-piperidinyl)acetamide; NCE, normochromatic erythrocytes; PCE, polychromatic erythrocytes; SBP, systolic blood pressure; Toxicity.