Abstract
Sixteen different sequence types (STs) of Escherichia coli isolates from a commercial swine farm in China were confirmed to coharbor the carbapenem resistance gene blaNDM-5 and the colistin resistance gene mcr-1 Whole-genome sequencing revealed that blaNDM-5 and mcr-1 were located on a 46-kb IncX3 plasmid and a 32-kb IncX4 plasmid, respectively. The two plasmids can transfer together with a low fitness cost, which might explain the presence of various STs of E. coli coharboring blaNDM-5 and mcr-1.
Keywords:
Escherichia coli; blaNDM-5; carbapenems; colistin; fitness cost; mcr-1.
Copyright © 2017 American Society for Microbiology.
MeSH terms
-
Animals
-
Anti-Bacterial Agents / pharmacology
-
Carbapenems / pharmacology
-
China / epidemiology
-
Colistin / pharmacology
-
Drug Resistance, Multiple, Bacterial / genetics*
-
Escherichia coli / drug effects
-
Escherichia coli / genetics*
-
Escherichia coli / growth & development
-
Escherichia coli / isolation & purification
-
Escherichia coli Infections / epidemiology
-
Escherichia coli Infections / microbiology
-
Escherichia coli Infections / veterinary*
-
Escherichia coli Proteins / genetics*
-
Escherichia coli Proteins / metabolism
-
Gene Expression
-
Gene Transfer, Horizontal
-
Genetic Fitness
-
Genotype
-
Plasmids / chemistry
-
Plasmids / genetics
-
Plasmids / metabolism
-
Swine
-
Swine Diseases / epidemiology*
-
Swine Diseases / microbiology
-
beta-Lactamases / genetics*
-
beta-Lactamases / metabolism
Substances
-
Anti-Bacterial Agents
-
Carbapenems
-
Escherichia coli Proteins
-
MCR-1 protein, E coli
-
beta-Lactamases
-
Colistin