Hypertranscription in Development, Stem Cells, and Regeneration

Abstract

Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.

Keywords: Chd1; Myc; cell competition; cell number normalization; development; hypertranscription; open chromatin; proliferation; regeneration; self-renewal; stem cells.