Abstract
Accompanied by other rare compounds, a new iridoid dimer, named kurdnestorianoside (1), showing an unprecedented secologanol configuration, has been isolated for the first time from the Kurdish medicinal plant Pterocephalus nestorianus, which is used in Kurdistan for treating oral diseases and inflammation. The structure of 1 was established from 1D- and 2D-NMR spectroscopic data. Kaempferol 3-O-[3,6-di-O-(E)-p-coumaroyl]-β-d-glucopyranoside (7) showed a remarkable antiproliferative activity against several human tumor cell lines.
Keywords:
Pterocephalus nestorianus; Cytotoxic activities; Dipsacaceae; Iridoid dimers; Kurdish medicinal plant.
© 2017 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dipsacaceae / chemistry*
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Dipsacaceae / metabolism
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Drug Screening Assays, Antitumor
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Flowers / chemistry
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Flowers / metabolism
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Humans
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Iridoids / chemistry*
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Iridoids / isolation & purification
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Iridoids / toxicity
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Kaempferols / chemistry
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Kaempferols / isolation & purification
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Kaempferols / toxicity
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Magnetic Resonance Spectroscopy
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Plants, Medicinal / chemistry
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Plants, Medicinal / metabolism
Substances
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Antineoplastic Agents, Phytogenic
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Iridoids
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Kaempferols
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kurdnestorianoside
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kaempferol