Abstract
The authors produced immunotoxin by coupling the diphtheria toxin fragment A to the monoclonal antibody against a human glioma cell line. This toxin selectively inhibited protein synthesis of glioma cells in culture.
MeSH terms
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Antibodies, Monoclonal / therapeutic use*
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Antibody Specificity
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Brain Neoplasms / immunology
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Cell Line
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Cell Survival / drug effects
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Diphtheria Toxin / therapeutic use*
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Glioma / immunology
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Humans
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Immunotoxins / therapeutic use*
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Peptide Fragments / therapeutic use*
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Tumor Cells, Cultured / drug effects*
Substances
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Antibodies, Monoclonal
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Diphtheria Toxin
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Immunotoxins
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Peptide Fragments
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diphtheria toxin fragment A