Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

A M Mohammed; L Velazquez; A Chisenhall; D Schiffels; D K Fygenson; R Schulman

doi:10.1039/c6nr06983e

Self-assembly of precisely defined DNA nanotube superstructures using DNA origami seeds

Nanoscale. 2017 Jan 5;9(2):522-526. doi: 10.1039/c6nr06983e.

Authors

A M Mohammed¹, L Velazquez², A Chisenhall¹, D Schiffels², D K Fygenson³, R Schulman⁴

Affiliations

¹ Chemical and Biomolecular Engineering, Johns Hopkins University, USA. rschulm3@jhu.edu.
² Department of Physics, University of California Santa Barbara, USA.
³ Department of Physics, University of California Santa Barbara, USA and Biomolecular Science and Engineering, University of California Santa Barbara, USA.
⁴ Chemical and Biomolecular Engineering, Johns Hopkins University, USA. rschulm3@jhu.edu and Computer Science, Johns Hopkins University, USA.

PMID: 27957574
DOI: 10.1039/c6nr06983e

Abstract

We demonstrate a versatile process for assembling micron-scale filament architectures by controlling where DNA tile nanotubes nucleate on DNA origami assemblies. "Nunchucks," potential mechanical magnifiers of nanoscale dynamics consisting of two nanotubes connected by a dsDNA linker, form at yields sufficient for application and consistent with models.

MeSH terms

DNA / chemistry*
Nanotubes / chemistry*
Nucleic Acid Conformation*

Substances

DNA