Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications

Chem Commun (Camb). 2017 Jan 24;53(8):1366-1369. doi: 10.1039/c6cc08292k.

Abstract

Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.

MeSH terms

  • Aminoglycosides* / analysis
  • Aminoglycosides* / chemistry
  • Aminoglycosides* / pharmacology
  • Aminoglycosides* / therapeutic use
  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Methicillin-Resistant Staphylococcus aureus / cytology
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Probes* / analysis
  • Molecular Probes* / chemistry
  • Molecular Probes* / pharmacology
  • Molecular Probes* / therapeutic use
  • Molecular Structure
  • Neomycin / analogs & derivatives
  • Neomycin / chemistry
  • Neomycin / pharmacology
  • Neomycin / therapeutic use
  • Particle Size
  • RAW 264.7 Cells
  • Staphylococcal Infections / diagnosis*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / therapy*

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Molecular Probes
  • Neomycin