Complex Trait Analyses of the Collaborative Cross: Tools and Databases

Methods Mol Biol. 2017:1488:121-129. doi: 10.1007/978-1-4939-6427-7_5.

Abstract

The Collaborative cross (CC) is a powerful mouse resource for investigating complex genetic traits. Here we discuss various tools and techniques for gene mapping and identification using the CC. The data analyses procedures are illustrated with examples.

Keywords: Analysis tools in systems genetics; Collaborative Cross; Haplotype analysis; Imputation; Mixed model; Quantitative trait loci (QTL) mapping methods; Whole-genome association.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping / methods
  • Computational Biology / methods
  • Crosses, Genetic*
  • Data Mining
  • Databases, Nucleic Acid*
  • Genetics, Population / methods
  • Genome
  • Genome-Wide Association Study
  • Genomics / methods
  • Genotype
  • Haplotypes
  • Mice
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • Quantitative Trait, Heritable*
  • Software*
  • User-Computer Interface