To systematically review the potential value of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) as a potential novel prognostic biomarker in cancers. Methods: Databases including Cochrane Library, Medline, Embase, PubMed databases were searched for all English studies, which explored the correlation between lncRNA MALAT1 expression and overall survival in tumors. The retrieval time was from inception to August 1, 2015. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality. Then, Meta-analysis was performed using RevMan 5.3 software. Results: Ten studies covered a total of 1 016 patients. Meta-analysis showed that high expression of MALAT1 was significantly correlated to poor overall survival (OS) in patients with tumor (HR= 2.08, 95% CI 1.74 to 2.48, P<0.001). Conclusion: LncRNA MALAT1 might be a potential novel prognostic biomarker in tumor.
目的：系统评价长链非编码RNA(long noncoding RNA，lncRNA)转移相关性肺腺癌转录因子1(metastasis-associated lung adenocarcinoma transcript 1，MALAT1)作为一种新型生物标志物判断肿瘤预后的潜在价值。方法：计算机检索Cochrane Library，Medline，Embase，PubMed等数据库中从建库到2015年8月1日前关于lncRNA MALAT1表达与肿瘤患者总生存期相关性的英文文献。由2名研究者根据纳入与排除标准对文献进行独立筛选、提取资料和评价质量后，采用RevMan 5.3软件进行Meta分析。结果：最终纳入10篇文献，共1 016例患者。Meta分析结果显示lncRNA MALAT1的高表达与肿瘤患者的低总生存期密切相关(HR=2.08，95% CI：1.74~2.48，P<0.001)。结论：LncRNA MALAT1可作为一种判断肿瘤预后的新型生物标志物。.