ULK1 cycling: The ups and downs of the autophagy response

Yan G Zhao; Hong Zhang

doi:10.1083/jcb.201611177

ULK1 cycling: The ups and downs of the autophagy response

J Cell Biol. 2016 Dec 19;215(6):757-759. doi: 10.1083/jcb.201611177. Epub 2016 Dec 8.

Authors

Yan G Zhao¹, Hong Zhang^{2

3}

Affiliations

¹ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
² National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China hongzhang@sun5.ibp.ac.cn.
³ College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

The Ser/Thr kinase ULK1/Atg1 controls autophagy initiation under nutrient starvation conditions. In this issue, Nazio et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605089) demonstrate that oscillatory modulation of NEDD4L-mediated proteasomal degradation and mTOR-dependent de novo protein synthesis of ULK1 ensures the proper amplitude and duration of the autophagy response during prolonged starvation, thus maintaining cellular homeostasis.

MeSH terms

Animals
Autophagy*
Autophagy-Related Protein-1 Homolog / metabolism*
Endosomal Sorting Complexes Required for Transport / metabolism
HeLa Cells
Humans
Mice
Models, Biological
Nedd4 Ubiquitin Protein Ligases
Ubiquitin / metabolism
Ubiquitin-Protein Ligases / metabolism
Ubiquitination

Substances

Endosomal Sorting Complexes Required for Transport
Ubiquitin
Nedd4 Ubiquitin Protein Ligases
Nedd4L protein, human
Nedd4l protein, mouse
Ubiquitin-Protein Ligases
Autophagy-Related Protein-1 Homolog