Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium

Physiology (Bethesda). 2017 Jan;32(1):20-32. doi: 10.1152/physiol.00021.2016.

Abstract

Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alzheimer Disease / metabolism
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Atherosclerosis / metabolism
  • Brain / blood supply*
  • Brain / metabolism*
  • Cardiovascular System / metabolism
  • Endothelium, Vascular / metabolism*
  • Epoprostenol / metabolism
  • Humans
  • Mice
  • Mice, Transgenic
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Nitrous Oxide / metabolism
  • Proteolysis

Substances

  • Amyloid beta-Protein Precursor
  • Epoprostenol
  • Nitrous Oxide