Abstract
Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.
©2017 Int. Union Physiol. Sci./Am. Physiol. Soc.
Publication types
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Review
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Alzheimer Disease / metabolism
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Amyloid beta-Protein Precursor / genetics
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Amyloid beta-Protein Precursor / metabolism*
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Animals
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Atherosclerosis / metabolism
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Brain / blood supply*
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Brain / metabolism*
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Cardiovascular System / metabolism
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Endothelium, Vascular / metabolism*
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Epoprostenol / metabolism
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Humans
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Mice
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Mice, Transgenic
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Neovascularization, Pathologic
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Neovascularization, Physiologic
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Nitrous Oxide / metabolism
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Proteolysis
Substances
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Amyloid beta-Protein Precursor
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Epoprostenol
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Nitrous Oxide