Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

Eugene H Chang; Amanda L Willis; Hilary C McCrary; George T Noutsios; Christopher H Le; Alexander G Chiu; Corrine J Mansfield; Danielle R Reed; Steven G Brooks; Nithin D Adappa; James N Palmer; Noam G Cohen; Debra A Stern; Stefano Guerra; Fernando D Martinez

doi:10.1016/j.jaci.2016.10.027

Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis

J Allergy Clin Immunol. 2017 Jun;139(6):1990-1992.e2. doi: 10.1016/j.jaci.2016.10.027. Epub 2016 Dec 3.

Authors

Affiliations

¹ Department of Otolaryngology, University of Arizona, Tucson, Ariz. Electronic address: echang@oto.arizona.edu.
² Department of Otolaryngology, University of Arizona, Tucson, Ariz.
³ Monell Chemical Senses Center, Philadelphia, Pa.
⁴ Department of Otolaryngology, University of Pennsylvania, Philadelphia, Pa.
⁵ Monell Chemical Senses Center, Philadelphia, Pa; Department of Otolaryngology, University of Pennsylvania, Philadelphia, Pa; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pa.
⁶ Asthma and Airway Disease Research Center, University of Arizona, Tucson, Ariz.

Abstract

A retrospective, multi-center study of adults with and without chronic rhinosinusitis (CRS) identifies a significant association between rs6967330 in the viral receptor CDHR3 – known to be associated with wheezing and asthma in children – and the development of CRS.

Publication types

Letter
Research Support, N.I.H., Extramural

MeSH terms

Age Factors
Alleles*
Cadherin Related Proteins
Cadherins / genetics*
Chronic Disease
Female
Genetic Association Studies
Genetic Predisposition to Disease*
Humans
Male
Membrane Proteins / genetics*
Multicenter Studies as Topic
Odds Ratio
Polymorphism, Single Nucleotide
Retrospective Studies
Rhinitis / genetics*
Sex Factors
Sinusitis / genetics*

Substances

CDHR3 protein, human
Cadherin Related Proteins
Cadherins
Membrane Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding