Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016

Euro Surveill. 2016 Nov 17;21(46):30402. doi: 10.2807/1560-7917.ES.2016.21.46.30402.

Abstract

We report 59 cases of severe paediatric conditions linked with enterovirus (EV)-A71 and EV-D68 in France between May and October 2016. Fifty-two children had severe neurological symptoms. EV sequence-based typing for 42 cases revealed EV-A71 in 21 (18 subgenotype C1, detected for the first time in France) and EV-D68 in eight. Clinicians should be encouraged to obtain stool and respiratory specimens from patients presenting with severe neurological disorders for EV detection and characterisation.

Keywords: Enterovirus A71; Enterovirus D68; France; children; severe neurological symptoms.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Coinfection / epidemiology
  • Coinfection / virology*
  • Enterovirus A, Human / genetics
  • Enterovirus A, Human / isolation & purification*
  • Enterovirus D, Human / genetics
  • Enterovirus D, Human / isolation & purification*
  • Enterovirus Infections / diagnosis
  • Enterovirus Infections / epidemiology*
  • Enterovirus Infections / virology
  • Female
  • France / epidemiology
  • Genotype
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Male
  • Molecular Typing*
  • Nervous System Diseases / complications
  • Nervous System Diseases / virology*
  • Phylogeny
  • Respiratory Tract Infections / diagnosis*
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / virology
  • Sentinel Surveillance
  • Sequence Analysis, DNA
  • Severity of Illness Index