Parental origin of chromosomal nondisjunction in a 49,XXXXY male using recombinant-DNA techniques

Clin Genet. 1989 Sep;36(3):152-5. doi: 10.1111/j.1399-0004.1989.tb03181.x.

Abstract

We have analyzed the origin, in a patient with 49,XXXXY, of the four X-chromosomes by means of recombinant DNA techniques. We found a maternal origin of the four X-chromosomes due to non-disjunctions in the first and second meiotic divisions.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • DNA Probes
  • DNA, Recombinant*
  • Facial Bones / abnormalities
  • Genetic Linkage
  • Humans
  • Male
  • Meiosis
  • Mothers*
  • Nondisjunction, Genetic*
  • Polyploidy
  • Psychomotor Disorders / genetics
  • Sex Chromosome Aberrations / genetics*
  • Skull / abnormalities
  • X Chromosome*

Substances

  • DNA Probes
  • DNA, Recombinant