Mesenchymal Stem Cells and Their Role in Dental Medicine

Xueli Mao; Yao Liu; Chider Chen; Songtao Shi

doi:10.1016/j.cden.2016.08.006

Mesenchymal Stem Cells and Their Role in Dental Medicine

Dent Clin North Am. 2017 Jan;61(1):161-172. doi: 10.1016/j.cden.2016.08.006.

Authors

Xueli Mao¹, Yao Liu², Chider Chen³, Songtao Shi⁴

Affiliations

¹ Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Affiliated Stomatological Hospital, Sun Yat-sen University, 55 West Lingyuan Rd, Yuexiu District, Guangzhou 510055, China.
² Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pediatric Dentistry, School of Stomatology, China Medical University, 117 South Nanjing Street, Heping District, Shenyang 110002, China.
³ Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: songtaos@dental.upenn.edu.

PMID: 27912816
DOI: 10.1016/j.cden.2016.08.006

Abstract

Mesenchymal stem cells (MSCs) have been discovered in almost every organ and tissue. MSCs are a heterogeneous population of cells with the capacity to self-renew and show multilineage differentiation. MSCs possess immunomodulatory properties by regulating multiple types of immune cells. They are emerging as a promising therapeutic agent, and have been widely used for cell-based tissue regeneration and immune therapies. A further understanding of the biological characteristics of MSCs is a prerequisite to develop more efficient MSC-based therapies. This article reviews the current understanding of different MSC populations in orofacial tissue compared with those derived from bone marrow.

Keywords: Cell therapy; Dental stem cell; Immunomodulation; Mesenchymal stem cells; Tissue regeneration.

Publication types

Review

MeSH terms

Animals
Guided Tissue Regeneration, Periodontal* / methods
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells / physiology