Primary cilia: a link between hormone signalling and endocrine-related cancers?

Biochem Soc Trans. 2016 Oct 15;44(5):1227-1234. doi: 10.1042/BST20160149.

Abstract

Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes to tumourigenesis. This review considers the role of primary cilia in the pathogenesis of endocrine-related cancers.

Keywords: Von Hippel–Lindau; breast cancers; cilia; endocrine cancer; ovarian cancer; prostate cancer.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Axoneme / metabolism
  • Basal Bodies / metabolism
  • Cilia / metabolism*
  • Cilia / pathology
  • Endocrine Gland Neoplasms / metabolism
  • Endocrine Gland Neoplasms / pathology
  • Hormones / metabolism*
  • Humans
  • Models, Biological
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Signal Transduction*

Substances

  • Hormones