A flexible firmware architecture for different kinds of data acquisition systems, ranging from high-precision bench instruments to low-cost wireless transducers networks, is presented. The key component is a multi-behaviors finite state machine, easily configurable to both low- and high-performance requirements, to diverse operating systems, as well as to on-line and batch measurement algorithms. The proposed solution was validated experimentally on three case studies with data acquisition architectures: (i) concentrated, in a high-precision instrument for magnetic measurements at CERN, (ii) decentralized, for telemedicine remote monitoring of patients at home, and (iii) distributed, for remote monitoring of building's energy loss.