Role of the HTLV-1 viral factors in the induction of apoptosis

Mohammad Karimi; Hamed Mohammadi; Maryam Hemmatzadeh; Asadollah Mohammadi; Houshang Rafatpanah; Behzad Baradaran

doi:10.1016/j.biopha.2016.11.034

Role of the HTLV-1 viral factors in the induction of apoptosis

Biomed Pharmacother. 2017 Jan:85:334-347. doi: 10.1016/j.biopha.2016.11.034. Epub 2016 Nov 23.

Authors

Mohammad Karimi¹, Hamed Mohammadi², Maryam Hemmatzadeh², Asadollah Mohammadi³, Houshang Rafatpanah⁴, Behzad Baradaran⁵

Affiliations

¹ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Tabriz University of Medical Sciences, International Branch (Aras), Tabriz, Iran.
² Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Rafatpanahh@mums.ac.ir.
⁵ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Behzad_im@yahoo.com.

PMID: 27887847
DOI: 10.1016/j.biopha.2016.11.034

Abstract

Adult T-cell leukemia (ATL) and HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) are the two main diseases that are caused by the HTLV-1 virus. One of the features of HTLV-1 infection is its resistance against programmed cell death, which maintains the survival of cells to oncogenic transformation and underlies the viruses' therapeutic resistance. Two main genes by which the virus develops cancer are Tax and HBZ; playing an essential role in angiogenesis in regulating viral transcription and modulating multiple host factors as well as apoptosis pathways. Here we have reviewed by prior research how the apoptosis pathways are suppressed by the Tax and HBZ and new drugs which have been designed to deal with this suppression.

Keywords: Apoptosis; HBZ; HTLV-1; Tax.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / therapeutic use
Antiviral Agents / therapeutic use
Apoptosis Regulatory Proteins / metabolism
Apoptosis*
Basic-Leucine Zipper Transcription Factors / genetics
Basic-Leucine Zipper Transcription Factors / metabolism*
Cell Transformation, Viral
Gene Products, tax / genetics
Gene Products, tax / metabolism*
Genome, Viral
HTLV-I Infections / drug therapy
HTLV-I Infections / metabolism
HTLV-I Infections / pathology
HTLV-I Infections / virology*
Host-Pathogen Interactions
Human T-lymphotropic virus 1 / drug effects
Human T-lymphotropic virus 1 / genetics
Human T-lymphotropic virus 1 / metabolism*
Human T-lymphotropic virus 1 / pathogenicity
Humans
Leukemia-Lymphoma, Adult T-Cell / drug therapy
Leukemia-Lymphoma, Adult T-Cell / metabolism
Leukemia-Lymphoma, Adult T-Cell / pathology
Leukemia-Lymphoma, Adult T-Cell / virology*
Paraparesis, Tropical Spastic / drug therapy
Paraparesis, Tropical Spastic / metabolism
Paraparesis, Tropical Spastic / pathology
Paraparesis, Tropical Spastic / virology*
Retroviridae Proteins / genetics
Retroviridae Proteins / metabolism*

Substances

Antineoplastic Agents
Antiviral Agents
Apoptosis Regulatory Proteins
Basic-Leucine Zipper Transcription Factors
Gene Products, tax
HBZ protein, human T-cell leukemia virus type I
Retroviridae Proteins
tax protein, Human T-lymphotrophic virus 1